Substance P and Neprilysin in Chronic Pancreatitis
نویسندگان
چکیده
منابع مشابه
Expression of interleukin 8 (IL-8) and substance P in human chronic pancreatitis.
BACKGROUND Changes in substance P content and a relationship between the degree of perineural inflammation and pain has been demonstrated in chronic pancreatitis. Whether a relationship exists between neural alteration and pancreatic inflammation (neurogenic inflammation) is not known. AIMS In the present study we evaluated gene expression of preprotachykinin A (PPT-A), the gene encoding subs...
متن کاملpancreatitis, and chronic pancreatitis
EDITORIAL SYNOPSIS Two hundred and five confirmed cases of pancreatitis have been classified. Primary calcifying pancreatitis is associated with alcoholism. Pancreatic changes are patchy and related to plugging of minute ducts. Cysts are frequent. Obstruction to the main pancreatic duct may also result in chronic pancreatitis. Acute pancreatitis and acute recurrent pancreatitis are often associ...
متن کاملRole of substance P and the neurokinin 1 receptor in acute pancreatitis and pancreatitis-associated lung injury.
Substance P, acting via the neurokinin 1 receptor (NK1R), plays an important role in mediating a variety of inflammatory processes. However, its role in acute pancreatitis has not been previously described. We have found that, in normal mice, substance P levels in the pancreas and pancreatic acinar cell expression of NK1R are both increased during secretagogue-induced experimental pancreatitis....
متن کاملNeprilysin inhibition in chronic kidney disease
Despite current practice, patients with chronic kidney disease (CKD) are at increased risk of progression to end-stage renal disease and cardiovascular events. Neprilysin inhibition (NEPi) is a new therapeutic strategy with potential to improve outcomes for patients with CKD. NEPi enhances the activity of natriuretic peptide systems leading to natriuresis, diuresis and inhibition of the renin-a...
متن کاملSubstance P and Chronic Pain in Patients with Chronic Inflammation of Connective Tissue
OBJECTIVE Evidence suggests that substance P (SP) is involved in chronic joint inflammation, such as the pathogenesis of rheumatoid arthritis and osteoarthritis. The goal of the research was to evaluate the correlation between chronic pain and changes in the SP level in patients with chronic inflammation of the connective tissue. METHODS Patients with osteoarthritis and rheumatoid arthritis w...
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ژورنال
عنوان ژورنال: European Surgical Research
سال: 2012
ISSN: 1421-9921,0014-312X
DOI: 10.1159/000337869